Plant-assisted green biosynthesis of silver nanoparticles (NPs) has become the most powerful technique to prepare stable NPs. Macaranga indica is a medicinal plant widely available in the Western Ghats. It has varieties of medical properties like antibacterial, antioxidant, antidiabetic, cytotoxicity, and antidysentery and is commonly used in the traditional medicine system. This plant also contains polyphenols, flavonoids, and other plant constituents. Here, in this study, macaranga indica leaf extract is used as a capping agent for the synthesis of silver NPs by using the microwave irradiation technique. Synthesized NPs are characterized by using Uv-Vis Spectra, XRD, EDX, FESEM, and FTIR. Interpretation of characterization data reveals that synthesized NPs are in a spherical shape, monodispersed, and have particles the size of ~15-20 nm. These bicapped silver NPs have shown potential thermotolerant bacterial inhibition activity and are also efficient in methylene blue dye removal and hence can be used in the purification process of drinking water at its source.