In 2022, the 10 New Insights in Climate Science covers crucial topics that are key focus areas for negotiators at COP27, from adaptation and mitigation, to the intersections of climate and food systems, security, and finance: Questioning the myth of endless adaptation Vulnerability hotspots cluster in ‘regions at risk' New threats on the horizon from climate-health interactions Climate mobility: From evidence to anticipatory action Human security requires climate security Sustainable land use is essential to meeting climate targets Private sustainable finance practices are failing to catalyse deep transitions Loss and Damage: The urgent planetary imperative Inclusive decision-making for climate-resilient development Breaking down structural barriers and unsustainable lock-ins